Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry
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چکیده
منابع مشابه
Toxicity of aflatoxin B1 to penaeid shrimp.
Single intramuscular injections of aflatoxin B1 into the tail muscle of Penaeus stylirostris produced 24- and 96-h median lethal doses of 100.5 (78.3 to 129.0) and 49.5 (29.8 to 82.3) mg/kg, respectively. A toxicity curve showed no threshold at the levels tested. The mortality response in a feeding study with P. vannamei was not dose dependent, but tissue and organ damage were similar to that s...
متن کاملProtection of mitochondrial genetic system against aflatoxin B1 binding in animals resistant to aflatoxicosis.
Administration of a single dose of aflatoxin B1 (AFB1) (6 mg/kg) to Sprague-Dawley rats results in a high level of modification of hepatic mitochondrial DNA (2.1 nmol of AFB1 adducts per mumol DNA-phosphate) and long-term inhibition of mitochondrial transcription and translation activities (N. Bhat et al., Cancer Res., 42: 1876-1880, 1982). Similar doses of AFB1 given to ICR mice and Syrian gol...
متن کاملThe efficacy of various additives to reduce the toxicity of aflatoxin B1 in broiler chicks
Three-hundred and twenty 7-day-old Ross 308-strain broiler chickens were fed diets containing 0 or 125 ppb aflatoxin B 1 (AFB1) from 7 to 28 days of age. Sodium bentonite (0.5%), yeast (Saccharomyces cervisiae) 0.2%, hydrated sodium calcium aluminosilicate (HSCAS) (0.5%), ammonia (0.5%), formycine (0.1%), and toxiban (0.1%) were added to the basal diet, as fed basis to determine the effects of ...
متن کاملAssessment of aflatoxin B1 myocardial toxicity in rats: mitochondrial damage and cellular apoptosis in cardiomyocytes induced by aflatoxin B1
Objective The number of deaths from heart disease is increasing worldwide. Aflatoxin B1 (AFB1), a toxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus, is frequently detected in improperly processed/stored human food products. While AFB1 hepatotoxicity and carcinogenic properties have been well addressed, its myocardial toxicity is poorly documented. This study aimed to in...
متن کاملComparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cells.
Aflatoxin B(1) (AFB(1)) and fumonisin B(1) (FB(1)) are important food-borne mycotoxins. The co-contamination of food stuffs with these two mycotoxins is well known and has been possibly implicated in the development of human hepatocellular carcinoma in high risk regions around the world. In this study the acute and combinative toxicity of AFB(1) and FB(1) were tested in F-344 rats, mosquitofish...
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ژورنال
عنوان ژورنال: Agriculture
سال: 2015
ISSN: 2077-0472
DOI: 10.3390/agriculture5030742